BCL6-760

Chemical Structure : BCL6-760

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货号: PC-25827Not For Human Use, Lab Use Only.

BCL6-760 is a potent a potent, selective, heterobifunctional BCL6 ligand-directed degrader with EC50 of 1.4 nM and 0.8 nM in SU-DHL-4 and OCI-LY-1 cells respectively.

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25 mg		Get quote
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100 mg		Get quote

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生物&药学活性

BCL6-760 is a potent a potent, selective, heterobifunctional BCL6 ligand-directed degrader with EC50 of 1.4 nM and 0.8 nM in SU-DHL-4 and OCI-LY-1 cells respectively.
BCL6-760 potently inhibits OCI-LY-1 DLBCL cell line proliferation with GI50 of 1.3 nM.
BCL6-760 (15, 30, or 60 mg/kg BID) induces dose-dependent BCL6 degradation in OCI-LY-1 xenograft model in SCID mice.

物理化学性质&存储条件

分子量	715.26
分子式	C36H43ClN10O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(6-(4-((5-Chloro-4-((3-(3-hydroxy-3-methylbutyl)-1-methyl-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-5-yl)amino)pyrimidin-2-yl)(methyl)amino)piperidin-1-yl)-1-methyl-1H-indazol-3-yl)piperidine-2,6-dione

参考文献

1. Shunatona HP, et al. J Med Chem. 2025 Oct 23;68(20):21502-21519.

BCL6-760

生物&药学活性

物理化学性质&存储条件

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BCL6-760

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物理化学性质&存储条件

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