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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-Fungal-Azoffluxin
Azoffluxin

Chemical Structure : Azoffluxin

CAS No.: 2883514-82-5

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Azoffluxin (CMLD012336)

货号: PC-72457Not For Human Use, Lab Use Only.

Azoffluxin (CMLD012336) is a bis-benzodioxolylindolinone that synergizes with fluconazole against C. auris through the inhibition of efflux pump Cdr1, thus increasing intracellular fluconazole levels.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    Azoffluxin (CMLD012336) is a bis-benzodioxolylindolinone that synergizes with fluconazole against C. auris through the inhibition of efflux pump Cdr1, thus increasing intracellular fluconazole levels.
    Azoffluxin increases intracellular accumulation of fluconazole (FLC) by inhibiting Cdr1-mediated efflux in C. auris.
    Azoffluxin potentiates intracellular acting compounds against C. auris, to a similar degree as deletion of CDR1.
    Azoffluxin is active against diverse C. auris strains, azoffluxin potentiated fluconazole in multiple isolates from three of the four major clades. The clade III isolates from South Africa were the exception.
    Azoffluxin enhances fluconazole (FLC) activity against azole-resistant C. albicans isolates.
    Azoffluxin not only enhanced fluconazole activity but also reduced fungal burden by ~1000-fold as a single agent in mice infected with drug-resistant C. auris.

    物理化学性质&存储条件

    分子量 619.642
    分子式 C34H34FNO9
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    6-fluoro-3,3-bis(6-(((R)-2-hydroxy-4-methylpent-4-en-1-yl)oxy)benzo[d][1,3]dioxol-5-yl)indolin-2-one

    参考文献

    1. Kali R Iyer, et al. Nat Commun. 2020 Dec 22;11(1):6429.

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