Artesunate

Chemical Structure : Artesunate

CAS No.: 88495-63-0

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货号: PC-27146Not For Human Use, Lab Use Only.

规格	价格	库存
100 mg	￥580	In stock
250 mg	￥880	In stock
500 mg	￥1280	In stock
1 g	￥1980	In stock
5 g		Get quote

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生物&药学活性

Artesunate is an antimalarial and potent, hematin-dependent inhibitor of P. falciparum exported protein 1 (EXP1, PfMGST) with IC50 of 2.05 nM, inhibits EXP1 glutathione transferase activity toward hematin, also is a potential inhibitor of STAT-3.
Artesunate directly targets glucosylceramidase to suppress hepatocellular carcinoma proliferation and trigger apoptosis.
Artesunate inhibits IL-6 driven STAT-3-DNA binding activity with comparable potency to S3I-201 in a cell free system.
Artesunate interferes with STAT-3 dimerization and suppression of both constitutive and IL-6 inducible STAT-3 in vitro.
Artesunate also exhibitsselective cytotoxicity of cancer cells over normal cells in vitro.

物理化学性质&存储条件

分子量	384.43
分子式	C19H28O8
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-Oxo-4-(((3R,5aS,6R,8aS,9R,10R,12R,12aR)-3,6,9-trimethyldecahydro-3H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)butanoic acid

参考文献

1. Ilamathi M, et al. Curr Top Med Chem. 2016;16(22):2453-63.

2. Lisewski AM, et al. Cell. 2014 Aug 14;158(4):916-928.

3. Vandewynckel YP, et al. Eur J Gastroenterol Hepatol. 2014 Aug;26(8):861-70.

Artesunate

生物&药学活性

物理化学性质&存储条件

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Artesunate

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