Artefenomel |CAS:1029939-86-3 Probechem Biochemicals

Chemical Structure : Artefenomel

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Artefenomel (OZ439)

货号: PC-62987Not For Human Use, Lab Use Only.

Artefenomel (OZ439) is a novel, next-generation antimalarial ozonide that demonstrates high potentcy against P. falciparum in vitro and P. berghei in vivo (K1/NF54, IC50=2.0/3.2 nM)..

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生物&药学活性

Artefenomel (OZ439) is a novel, next-generation antimalarial ozonide that demonstrates high potentcy against P. falciparum in vitro and P. berghei in vivo (K1/NF54, IC50=2.0/3.2 nM).

Parasite Infection

Phase 2 Clinical

物理化学性质&存储条件

分子量	469.622
分子式	C28H39NO5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-[2-(4-cis-Dispiro[cyclohexane-1,3'-[1,2,4]trioxolane-5',2''-tricyclo[3.3.1.13,7]decan]-4-ylphenoxy)ethyl]morpholine

参考文献

1. Dong Y, et al. J Med Chem. 2017 Apr 13;60(7):2654-2668.

2. Kim HS, et al. J Med Chem. 2017 Apr 13;60(7):2651-2653.

3. Macintyre F, et al. BMC Med. 2017 Oct 9;15(1):181.

4. Yang T, et al. Antimicrob Agents Chemother. 2016 Jul 22;60(8):4501-10.

Artefenomel (OZ439)

生物&药学活性

物理化学性质&存储条件

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Artefenomel (OZ439)

生物&药学活性

物理化学性质&存储条件

参考文献

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