Antitrypanosomal agent 10

Chemical Structure : Antitrypanosomal agent 10

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货号: PC-21377Not For Human Use, Lab Use Only.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
200 mg		Get quote
1 g		Get quote

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生物&药学活性

Antitrypanosomal agent 10 is a potent, orally active antitrypanosomal compound, selectively inhibits the growth of parasites T. b. brucei, T. b. gambiense and T. b. rhodesiense with EC50 of 0.54, 0.13 and 1.14 uM, resepctively.
Antitrypanosomal agent 10 has excellent oral bioavailability and (100 mpk) is effective in treating acute infection of Human African Trypanosomiasis (HAT) in mouse models.

物理化学性质&存储条件

分子量	269.28
分子式	C10H11N3O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(E)-N-[4-(methylamino)-4-oxobut-2-en-1-yl]-5-nitrothiophene-2-carboxamide

参考文献

1. Ajayi O, et al. Eur J Med Chem. 2023 Nov 15;263:115954.