Chemical Structure : Antimalarial compound 49c
CAS No.:
1422207-75-7
Antimalarial compound 49c
货号: PC-35257Not For Human Use, Lab Use Only.
Antimalarial compound 49c is a potent antimalarial peptidomimetic inhibitor originally developed against Plasmepsin II selectively targets TgASP3, PfPMIX, and PfPMX, shows very potent antimalarial effects only after 72 h of treatment with IC50 of 0.6 nM.
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纯度 & COA & 质检文件 纯度:
>98% (HPLC)
生物&药学活性
Antimalarial compound 49c is a potent antimalarial peptidomimetic inhibitor originally developed against Plasmepsin II selectively targets TgASP3, PfPMIX, and PfPMX, shows very potent antimalarial effects only after 72 h of treatment with IC50 of 0.6 nM.
Antimalarial compound 49c blocks invasion and egress of P. falciparum without impacting intraerythrocytic growth, specifically inhibits recombinant PfPMIX and PfPMX (r-PMIXFlag and r-PMXFlag), recapitulating the defect in invasion and egress of P. falciparum in the erythrocytic blood stages.
Antimalarial compound 49c also interferes with invasion and egress in T. gondii by targeting TgASP3
物理化学性质&存储条件
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分子量
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514.67
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分子式
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C31H38N4O3
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外观性状
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Solid
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CAS No.
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储存条件
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- 固体粉末
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-20 °C 12 个月; 4°C 6 个月
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- 配置液
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-80 °C 6 个月; -20°C 6 个月
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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N-((2S,3R)-3-hydroxy-1-phenyl-4-(((R)-1-phenylethyl)amino)butan-2-yl)-4-(4-methylpiperazine-1-carbonyl)benzamide
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参考文献
1. Ciana C, et al. Bioorg Med Chem Lett. 2013 Feb 1;23(3):658-62.
2. Mukherjee B, et al. EMBO J. 2018 Apr 3;37(7). pii: e98047.
3. Pino P, et al. Science. 2017 Oct 27;358(6362):522-528.
4. Dogga SK, et al. Elife. 2017 Sep 12;6. pii: e27480.
