Amiselimod hydrochloride |CAS:942398-84-7 Probechem Biochemicals

Chemical Structure : Amiselimod hydrochloride

CAS No.: 942398-84-7

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Amiselimod hydrochloride (MT-1303 hydrochloride, MT1303 hydrochloride)

货号: PC-45066Not For Human Use, Lab Use Only.

Amiselimod (MT-1303) hydrochloride is a prodrug S1P1 receptor modulator lacking S1P3 receptor agonism to avoid bradycardia associated with fingolimod and other S1P receptor modulators.

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25 mg	￥2180	In stock
50 mg	￥3680	In stock
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生物&药学活性

Amiselimod (MT-1303) hydrochloride is a prodrug S1P1 receptor modulator lacking S1P3 receptor agonism to avoid bradycardia associated with fingolimod and other S1P receptor modulators.
Amiselimod shows potent selectivity for S1P1 and high selectivity for S1P5 receptors, with minimal agonist activity for S1P4 and no distinct agonist activity for S1P2 or S1P3 receptors and approximately five-fold weaker GIRK activation than fingolimod-P.
Amiselimod exhibits potent therapeutic efficacy with minimal cardiac effects.

物理化学性质&存储条件

分子量	413.9026
分子式	C19H31ClF3NO3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	DMSO: ≥ 32 mg/mL
Chemical Name/SMILES	1,3-Propanediol, 2-amino-2-[2-[4-(heptyloxy)-3-(trifluoromethyl)phenyl]ethyl]-, hydrochloride (1:1)

参考文献

1. Sugahara K, et al. Br J Pharmacol. 2017 Jan;174(1):15-27.

2. Kappos L, et al. Lancet Neurol. 2016 Oct;15(11):1148-59.

3. Harada T, et al. Br J Clin Pharmacol. 2017 May;83(5):1011-1027.

Amiselimod hydrochloride (MT-1303 hydrochloride, MT1303 hydrochloride)

生物&药学活性

物理化学性质&存储条件

参考文献

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Amiselimod hydrochloride (MT-1303 hydrochloride, MT1303 hydrochloride)

生物&药学活性

物理化学性质&存储条件

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