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首页-小分子抑制剂&激动剂-GPCR-Histamine Receptor-Adriforant
Adriforant

Chemical Structure : Adriforant

CAS No.: 943057-12-3

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Adriforant (PF-3893787,ZPL-3893787, ZPL-389, PF-03893787)

货号: PC-61567Not For Human Use, Lab Use Only.

Adriforant (PF-3893787, ZPL 3893787) is a potent and selective H4 receptor antagonist with binding Ki of 2.4 nM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    Adriforant (PF-3893787, ZPL 3893787) is a potent and selective H4 receptor antagonist with binding Ki of 2.4 nM.
    Adriforant (PF-3893787, ZPL 3893787) has an IC50 of 1.16 nM on human native isolated eosinophils assessing actin polymerisation.
    Adriforant (PF-3893787, ZPL 3893787) exhibits anti-inflammatory activity.

    物理化学性质&存储条件

    分子量 262.361
    分子式 C13H22N6
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    4-N-(cyclopropylmethyl)-6-[(3R)-3-(methylamino)pyrrolidin-1-yl]pyrimidine-2,4-diamine

    参考文献

    1. Mowbray CE, et al. Bioorg Med Chem Lett. 2011 Nov 1;21(21):6596-602.

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