AZD8683 |CAS:1194737-07-9 Probechem Biochemicals

Chemical Structure : AZD8683

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AZD8683 (AZD-8683;AZD 8683)

货号: PC-61046Not For Human Use, Lab Use Only.

AZD8683 (AZD-8683) is a highly potent, long acting muscarinic receptor M3 antagonist with pIC50 of 9.8, inhibits M3 receptor in guinea pig trachea with pA2 of 9.4.

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生物&药学活性

AZD8683 (AZD-8683) is a highly potent, long acting muscarinic receptor M3 antagonist with pIC50 of 9.8, inhibits M3 receptor in guinea pig trachea with pA2 of 9.4.
AZD8683 reverses airflow obstruction by antagonizing para-sympathetic bronchoconstricting effects within the airways.
AZD8683 shows potential for chronic obstructive pulmonary disease (COPD) management.

物理化学性质&存储条件

分子量	542.518
分子式	C28H36BrN3O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-1-(2-oxo-2-(pyridin-2-ylamino)ethyl)-3-((1-phenylcycloheptane-1-carbonyl)oxy)quinuclidin-1-ium bromide

参考文献

1. Mete A, et al. Bioorg Med Chem Lett. 2013 Dec 1;23(23):6248-53.

2. Mastrodicasa MA, et al. Expert Opin Investig Drugs. 2017 Feb;26(2):161-174.

AZD8683 (AZD-8683;AZD 8683)

生物&药学活性

物理化学性质&存储条件

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AZD8683 (AZD-8683;AZD 8683)

生物&药学活性

物理化学性质&存储条件

参考文献

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