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首页-小分子抑制剂&激动剂-Tyrosine Kinase-Trk Receptor-AZD1332
AZD1332

Chemical Structure : AZD1332

CAS No.: 2649758-84-7

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AZD1332 (AZD-1332)

货号: PC-63149Not For Human Use, Lab Use Only.

AZD1332 is a potent, selective, ATP-competitive neurotrophic tyrosine kinase receptor (NRTK, TRK) inhibitor with IC50 of <10 nM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    AZD1332 is a potent, selective, ATP-competitive neurotrophic tyrosine kinase receptor (NRTK, TRK) inhibitor with IC50 of <10 nM.
    AZD1332 inhibits phosphorylation of TrkA/B/C in MCF10A cells overexpressing TrkA and NIH3T3 cells over expressing TrkA, TrkB, or TrkC with IC50 of <5 nM.
    AZD1332 inhibits a panel Baf3 survival driven by TrkA, TrkB, or TrkC with EC50 of 2 nM, AZD 1332 is orally available.

    物理化学性质&存储条件

    分子量 391.835
    分子式 C17H19ClFN7O
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    5-chloro-2-N-[1-(5-fluoropyridin-2-yl)ethyl]-4-N-(3-propan-2-yloxy-1H-pyrazol-5-yl)pyrimidine-2,4-diamine

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