AZ-23 | Trk inhibitor | Probechem Biochemicals

Chemical Structure : AZ-23

CAS No.: 915720-21-7

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AZ-23 (AZ23)

货号: PC-63210Not For Human Use, Lab Use Only.

AZ-23 is a potent, selective, orally bioavailable Trk kinase inhibitor with IC50 of 2 and 8 nM for TrkA and TrkB, respectively.

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5 mg	￥1980	In stock
10 mg	￥3280	In stock
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生物&药学活性

AZ-23 is a potent, selective, orally bioavailable Trk kinase inhibitor with IC50 of 2 and 8 nM for TrkA and TrkB, respectively.
AZ-23 displays >10-fold specificity for TrkA versus FGFR1 and >25-fold over a broad panel of kinases.
AZ-23 potently inhibits NGF-induced TrkA/B/C phosphorylation in NIH-3T3 cells with IC50 of 2 nM, 25-fold window of selectivity versus FGFR, Flt3, Ret, and Lck kinases.
AZ-23 exhibits significant tumor growth inhibition in Trk-expressing xenograft model of neuroblastoma.

物理化学性质&存储条件

分子量	391.83
分子式	C17H19ClFN7O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2,4-Pyrimidinediamine, 5-chloro-N2-((1S)-1-(5-fluoro-2-pyridinyl)ethyl)-N4-(5-(1-methylethoxy)-1H-pyrazol-3-yl)-

参考文献

1. Thress K, et al. Mol Cancer Ther. 2009 Jul;8(7):1818-27.

2. Wang T, et al. J Med Chem. 2008 Aug 14;51(15):4672-84.

3. Chen S, et al. Cell Oncol (Dordr). 2018 Feb;41(1):93-101.

AZ-23 (AZ23)

生物&药学活性

物理化学性质&存储条件

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AZ-23 (AZ23)

生物&药学活性

物理化学性质&存储条件

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