AWZ1066S | Wolbachia inhibitor | Probechem Biochemicals

Chemical Structure : AWZ1066S

CAS No.: 2239272-16-1

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AWZ1066S (AWZ1066 S-form)

货号: PC-21811Not For Human Use, Lab Use Only.

AWZ1066S is a potent, highly specific anti-Wolbachia inhibitor with EC50 of 2.5 nM against Wolbachia in cell-based assays, and IC50 of 121 nM in microfilaria assays.

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5 mg	￥1580	In stock
10 mg	￥2480	In stock
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

AWZ1066S is a potent, highly specific anti-Wolbachia inhibitor with EC50 of 2.5 nM against Wolbachia in cell-based assays, and IC50 of 121 nM in microfilaria assays.
AWZ1066 reduces Wolbachia within the microfilariae (mf) of the human parasite B. malayiwith an EC50 of 150 nM.
AWZ1066S (100 mg/kg) reduces Wolbachia by 98% after only 7 d orally administered treatment in adult B. malayi SCID mouse model.
AWZ1066S shows minimal impact on the gut microbiota, lowering the risk of dysbiosis and the selection and emergence of resistance.

物理化学性质&存储条件

分子量	404.40
分子式	C19H19F3N6O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-[(3S)-3-Methyl-4-morpholinyl]-N-[[2-(trifluoromethyl)-3-pyridinyl]methyl]pyrido[2,3-d]pyrimidin-4-amine

参考文献

1. Hong W. D. et al. Proc. Natl. Acad. Sci. U. S. A. 116, 1414–1419.

AWZ1066S (AWZ1066 S-form)

生物&药学活性

物理化学性质&存储条件

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AWZ1066S (AWZ1066 S-form)

生物&药学活性

物理化学性质&存储条件

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