ATR-127 | β2/β3-adrenoceptor agonist | Probechem Biochemicals

Chemical Structure : ATR-127

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ATR-127 (ATR127)

货号: PC-22446Not For Human Use, Lab Use Only.

ATR-127 is a highly effective β2- and β3-adrenoceptors (ARs) agonist with pEC50 of 6.53 and 5.5 for rat β2-AR and mouse β3-AR, respectively.

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生物&药学活性

ATR-127 is a highly effective β2- and β3-adrenoceptors (ARs) agonist with pEC50 of 6.53 and 5.5 for rat β2-AR and mouse β3-AR, respectively.
ATR-127 is a full agonist but with a reduced potency compared to isoprenaline.
ATR-127 displayed weaker partial agonist activity compared to isoprenaline for rat β1-AR. exhibits differential cAMP generation capability and minimal desensitization response.
ATR-127 increases glucose uptake in skeletal muscle by stimulating β2-adrenoceptors.
ATR-127 induces glucose uptake and thermogenesis in brown adipocytes.
Chronic ATR-127 treatment improves glucose tolerance and body composition in DIO mice.

物理化学性质&存储条件

分子量	223.32
分子式	C13H21NO2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-((R)-1-hydroxy-2-(((R)-pentan-2-yl)amino)ethyl)phenol

参考文献

1. Emanuela Talamonti, et al. Mol Metab. 2024 May 17:101931.

ATR-127 (ATR127)

生物&药学活性

物理化学性质&存储条件

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ATR-127 (ATR127)

生物&药学活性

物理化学性质&存储条件

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