ASP6432 |CAS:1282549-08-9 Probechem Biochemicals

Chemical Structure : ASP6432

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ASP6432 (ASP 6432;ASP-6432)

货号: PC-35197Not For Human Use, Lab Use Only.

ASP6432 (ASP-6432) is a potent and selective antagonist of LPA1 receptor, does-dependently inhibits LPA-stimulated increase in intracellular calcium ion with IC50 of 11 nM.

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生物&药学活性

ASP6432 (ASP-6432) is a potent and selective antagonist of LPA1 receptor, does-dependently inhibits LPA-stimulated increase in intracellular calcium ion with IC50 of 11 nM.
ASP6432 also inhibits the LPA-induced [Ca2+]i increase in cells expressing rat LPA1 (IC50=30 nM), weakly inhibits LPA-induced [Ca2+]i increase in cells expressing human LPA4 (IC50=114 nM), and shows no activity on LAP2/3.
ASP6432 inhibits LPA-induced urethra and prostate contractions in isolated rat tissue strips and anesthetized rats, decreases the urethral perfusion pressure (UPP) anesthetized rats.

物理化学性质&存储条件

分子量	598.774
分子式	C26H31KN4O6S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-((3,5-dimethoxy-4-methyl-N-(3-phenylpropyl)benzamido)methyl)-N-(N-ethylsulfamoyl)thiazole-4-carboxamide, potassium salt

参考文献

1. Sakamoto K, et al. J Pharmacol Exp Ther. 2018 Jun 8. pii: jpet.118.247908.

ASP6432 (ASP 6432;ASP-6432)

生物&药学活性

物理化学性质&存储条件

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ASP6432 (ASP 6432;ASP-6432)

生物&药学活性

物理化学性质&存储条件

参考文献

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