AS408 | β2AR modulator | Probechem Biochemicals

Chemical Structure : AS408

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AS408 (AS-408)

货号: PC-49058Not For Human Use, Lab Use Only.

AS408 is a negative allosteric modulator of the β2-adrenergic receptor (β2AR) for both G-protein activation and arrestin recruitment (pKB=6.8, [35S]GTPγS binding assays), binds to a pocket formed by the membrane-facing surface of TM3 and TM5.

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生物&药学活性

AS408 is a negative allosteric modulator of the β2-adrenergic receptor (β2AR) for both G-protein activation and arrestin recruitment (pKB=6.8, [35S]GTPγS binding assays), binds to a pocket formed by the membrane-facing surface of TM3 and TM5.
AS408 exhibits negative allosteric regulation of norepinephrine-stimulated arrestin recruitment and cAMP accumulation.
AS408 can stabilize TM5 in an inactive conformation does not bind to the G protein-stabilized active state of the β2AR.

物理化学性质&存储条件

分子量	315.174
分子式	C14H11BrN4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	6-bromo-N2-phenylquinazoline-2,4-diamine

参考文献

1. Liu X, et al. Nat Chem Biol. 2020 Jul;16(7):749-755.

AS408 (AS-408)

生物&药学活性

物理化学性质&存储条件

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AS408 (AS-408)

生物&药学活性

物理化学性质&存储条件

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