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首页-抗体药物偶连体和PROTACs-PROTAC-ARV-393
ARV-393

Chemical Structure : ARV-393

CAS No.: 2851885-95-3

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ARV-393 (ARV393)

货号: PC-22120Not For Human Use, Lab Use Only.

ARV-393 is a potent, orally bioavailable BCL6 targeting PROTAC degrader with DC50 and GI50 values <1 nM in numerous DLBCL and BL cell lines.

规格 价格 库存 数量
2 mg ￥2380 In stock
5 mg ￥3980 In stock
10 mg ￥5980 In stock
25 mg Get quote
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纯度 & COA & 质检文件 纯度: 99.59% (HPLC) Select Batch:

生物&药学活性

ARV-393 is a potent, orally bioavailable BCL6 targeting PROTAC degrader with DC50 and GI50 values <1 nM in numerous DLBCL and BL cell lines.
ARV-393 recruits BCL6 and the E3 ligase cereblon to rapidly degrade BCL6 via the cell's natural ubiquitin proteasome system.
ARV-393 demonstrates deep BCL6 degradation in vitro and in vivo, resulting in excellent TGI in several tumor xenograft models.

物理化学性质&存储条件

分子量 898.43
分子式 C46H53ClFN9O7
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-[[6-[[5-Chloro-2-[4-[[trans-3-[4-[2-(2,6-dioxo-3-piperidinyl)-4-fluoro-2,3-dihydro-1-oxo-1H-isoindol-5-yl]-1-piperidinyl]cyclobutyl]oxy]-1-piperidinyl]-4-pyrimidinyl]amino]-1,2-dihydro-1-(1-methylethyl)-2-oxo-3-quinolinyl]oxy]-N-methylacetamide

参考文献

1. Dan Sherman. Cancer Res (2024) 84 (7_Supplement): ND05.

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