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首页-抗体药物偶连体和PROTACs-PROTAC-ARM165
ARM165

Chemical Structure : ARM165

CAS No.:

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ARM165 (ARM-165)

货号: PC-22441Not For Human Use, Lab Use Only.

ARM165 is a proteolysis-targeting chimera (PROTAC) heterobifunctional molecule that specifically degrades PIK3CG/p110γ, specifically degrades PIK3CG and potently suppresses AML.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

ARM165 is a proteolysis-targeting chimera (PROTAC) heterobifunctional molecule that specifically degrades PIK3CG/p110γ, specifically degrades PIK3CG and potently suppresses AML.

物理化学性质&存储条件

分子量 837.99
分子式 C44H51N7O8S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N1-(5-(2-((S)-1-cyclopropylethyl)-7-methyl-1-oxoisoindolin-5-yl)-4-methylthiazol-2-yl)-N5-(8-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-8-oxooctyl)glutaramide

参考文献

1. Kelly LM, et al. Nat Cancer. 2024 May 30. doi: 10.1038/s43018-024-00782-5.

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