ARCC-4 | AR degrader | Probechem Biochemicals

Chemical Structure : ARCC-4

CAS No.: 1973403-00-7

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ARCC-4 (ARCC4)

货号: PC-22554Not For Human Use, Lab Use Only.

ARCC-4 is a potent, selective enzalutamide-based von Hippel-Lindau (VHL)-recruiting androgen receptor (AR) degrader with DC50 of 5 nM in VCaP cells.

规格	价格	库存
5 mg	￥3280	In stock
10 mg	￥5280	In stock
25 mg		Get quote
50 mg		Get quote
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生物&药学活性

ARCC-4 is a potent, selective enzalutamide-based von Hippel-Lindau (VHL)-recruiting androgen receptor (AR) degrader with DC50 of 5 nM in VCaP cells.
ARCC-4 is better at overcoming resistance in cellular models of castration-resistant prostate cancer (CRPC).
ARCC-4 is better than enzalutamide at inducing apoptosis and inhibiting proliferation of AR-amplified prostate cancer cells.
ARCC-4 effectively degrades clinically relevant AR mutants associated with antiandrogen therapy, and maintains its potency to degrade AR and inhibit cell proliferation in a high androgen environment in which enzalutamide has no activity.

物理化学性质&存储条件

分子量	1024.18
分子式	C53H56F3N7O7S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2S,4R)-1-((S)-2-(2-(4-((4'-(3-(4-cyano-3-(trifluoromethyl)phenyl)-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl)-[1,1'-biphenyl]-4-yl)oxy)butoxy)acetamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide

参考文献

1. Salami J, et al. Commun Biol. 2018 Aug 2;1:100.

ARCC-4 (ARCC4)

生物&药学活性

物理化学性质&存储条件

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ARCC-4 (ARCC4)

生物&药学活性

物理化学性质&存储条件

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