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首页-小分子抑制剂&激动剂-Wnt/Notch/Hedgehog-Casein Kinase-ARC-1502
ARC-1502

Chemical Structure : ARC-1502

CAS No.: 1569315-51-0

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ARC-1502 (ARC1502)

货号: PC-22272Not For Human Use, Lab Use Only.

ARC-1502 is a potent, selective bisubstrate inhibitor of protein kinase CK2 (Casein kinase II) with Ki of 0.56 nM, addressing the ATP site and the substrate-binding site of CK2. interferes with both sub-interfaces of the bipartite CK2α/CK2β interaction.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

ARC-1502 is a potent, selective bisubstrate inhibitor of protein kinase CK2 (Casein kinase II) with Ki of 0.56 nM, addressing the ATP site and the substrate-binding site of CK2. interferes with both sub-interfaces of the bipartite CK2α/CK2β interaction.

物理化学性质&存储条件

分子量 1394.62
分子式 C45H58Br4N10O21
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(8-(4,5,6,7-tetrabromo-1H-benzo[d]imidazol-1-yl)octanoyl)-D-aspartyl-L-aspartyl-L-aspartyl-L-aspartyl-L-aspartyl-L-aspartyl-L-lysine

参考文献

1. Markus Pietsch, et al. Bioorg Chem. 2020 Mar:96:103608.

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