ANA-12 |CAS:219766-25-3 Probechem Biochemicals

Chemical Structure : ANA-12

CAS No.: 219766-25-3

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ANA-12 (ANA12)

货号: PC-43064Not For Human Use, Lab Use Only.

ANA-12 is a selective TrkB antagonist that binds TrkB ECD-Fc with Kd of 12 uM, prevents BDNF-induced neurite outgrowth (at 10 nM), inhibits processes downstream of TrkB without altering TrkA and TrkC functions.

规格	价格	库存
25 mg	￥1680	In stock
50 mg	￥3480	In stock
100 mg	￥5680	In stock
250 mg		Get quote
1 g		Get quote

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生物&药学活性

ANA-12 is a selective TrkB antagonist that binds TrkB ECD-Fc with Kd of 12 uM, prevents BDNF-induced neurite outgrowth (at 10 nM), inhibits processes downstream of TrkB without altering TrkA and TrkC functions.
ANA-12 decreases TrkB activity in the brain without affecting neuronal survival, anxiolytic and antidepressant activity in mice.

物理化学性质&存储条件

分子量	407.4854
分子式	C22H21N3O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Benzo[b]thiophene-2-carboxamide, N-[2-[[(hexahydro-2-oxo-1H-azepin-3-yl)amino]carbonyl]phenyl]-

参考文献

1. Cazorla M, et al. J Clin Invest. 2011 May;121(5):1846-57.

2. Walsh JJ, et al. Nat Neurosci. 2014 Jan;17(1):27-9.

3. Chen W, et al. Eur J Neurosci. 2014 May;39(9):1439-54.

ANA-12 (ANA12)

生物&药学活性

物理化学性质&存储条件

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ANA-12 (ANA12)

生物&药学活性

物理化学性质&存储条件

参考文献

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