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首页-抗体药物偶连体和PROTACs-PROTAC-AN5777
AN5777

Chemical Structure : AN5777

CAS No.: 491586-42-6

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AN5777

货号: PC-23947Not For Human Use, Lab Use Only.

AN5777 is a potent GSPT1 degrader, binds recombinant CRBN and induces GSPT1 degradation through the UPS.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

AN5777 is a potent GSPT1 degrader, binds recombinant CRBN and induces GSPT1 degradation through the UPS.
AN5777 displaysgood antiproliferative activities against U937 and OCI-AML-2 cell with IC50 of 4.49 uM and 2.64 uM respectively.
AN5777 dose-dependently induces G1 phase arrest and apoptosis.

物理化学性质&存储条件

分子量 319.36
分子式 C19H17N3O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2,8-Dimethyl-3-quinolinecarboxylic acid 2-[(2-hydroxyphenyl)methylene]hydrazide

参考文献

1. Shuqun Zhang, et al. Eur J Med Chem. 2024 Jul 5:273:116524.

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