AKR1C3 PROTAC 5 | AKR1C3 degrader | Probechem Biochemicals

Chemical Structure : AKR1C3 PROTAC 5

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AKR1C3 PROTAC 5 (AKR1C3 degrader 5)

货号: PC-22253Not For Human Use, Lab Use Only.

AKR1C3 PROTAC 5 is a first-in-class Aldo-Keto reductase 1C3 (AKR1C3) PROTAC degrader with DC50 of 52 nM in 22Rv1 cells, AKR1C1/C2 DC50 of 49 nM, ARv7 DC50 of 70 nM.

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生物&药学活性

AKR1C3 PROTAC 5 is a first-in-class Aldo-Keto reductase 1C3 (AKR1C3) PROTAC degrader with DC50 of 52 nM in 22Rv1 cells, AKR1C1/C2 DC50 of 49 nM, ARv7 DC50 of 70 nM.
AKR1C3 PROTAC 5 is an effective degrader of AKR1C3, AKR1C1/2, and ARv7 in a concentration and proteasome dependent manner.
AKR1C3 PROTAC 5 reduces cell viability of in vitro prostate cancer models and potentiates enzalutamide through an AKR1C3-dependant effect.

物理化学性质&存储条件

分子量	841.88
分子式	C45H43N7O10
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(E)-3-(5-((4-((1-(2-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)amino)-2-oxoethoxy)ethoxy)ethyl)-1H-1,2,3-triazol-4-yl)methoxy)benzyl)carbamoyl)-[1,1'-biphenyl]-3-yl)acrylic acid

参考文献

1. Carmona AV, et al. Commun Chem. 2024 Apr 29;7(1):95.

AKR1C3 PROTAC 5 (AKR1C3 degrader 5)

生物&药学活性

物理化学性质&存储条件

参考文献

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AKR1C3 PROTAC 5 (AKR1C3 degrader 5)

生物&药学活性

物理化学性质&存储条件

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