ADU-S100 (MIW815, ML RR-S2 CDA) | STING agonist | Probechem Biochemicals

Chemical Structure : ADU-S100 disodium salt

CAS No.: 1638750-95-4

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ADU-S100 disodium salt (MIW815, 2’3’-c-di-AM(PS)2 (Rp,Rp), ML RR-S2 CDA)

货号: PC-62639Not For Human Use, Lab Use Only.

ADU-S100 (MIW815, ML RR-S2 CDA) disodium salt is a synthetic cyclic dinucleotide derivative that functions as a highly potent agonist of STING, enhances binding affinity to STING and activates all known human STING alleles.

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5 mg	￥4580	In stock
10 mg	￥7580	In stock
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生物&药学活性

ADU-S100 (MIW815, ML RR-S2 CDA) disodium salt is a synthetic cyclic dinucleotide derivative that functions as a highly potent agonist of STING, enhances binding affinity to STING and activates all known human STING alleles.

ADU-S100 shows enhanced type I IFN production over CDA in THP-1 human monocytes, induces the highest expression of IFN-β and the pro-inflammatory cytokines TNF-α, IL-6, and MCP-1 on a molar equivalent basis, as compared to endogenous ML cGAMP and the TLR3 agonist poly I:C.

ADU-S100 also induces aggregation of STING and induces phosphorylation of TBK1 and IRF3 in mouse BMM, induces significantly higher levels of IFN-α when compared to ML cGAMP.

ADU-S100 demonstrates profound anti-tumor efficacy in established B16 melanoma.

物理化学性质&存储条件

分子量	734.5
分子式	C20 H24 N10 O10 P2 S2 . 2 Na
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2R,5R,7R,8R,10R,12aR,14R,15R,15aS,16R)-7,14-Bis(6-amino-9H-purin-9-yl)-15,16-dihydroxy-2,10-dimercaptooctahydro-12H-5,8-methanofuro[3,2-l][1,3,6,9,11]pentaoxa[2,10]diphosphacyclotetradecine 2,10-dioxide disodium salt

参考文献

1. Cancer Discov. 2018 Jan 25. doi: 10.1158/2159-8290.CD-ND2018-002.

ADU-S100 disodium salt (MIW815, 2’3’-c-di-AM(PS)2 (Rp,Rp), ML RR-S2 CDA)

生物&药学活性

物理化学性质&存储条件

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ADU-S100 disodium salt (MIW815, 2’3’-c-di-AM(PS)2 (Rp,Rp), ML RR-S2 CDA)

生物&药学活性

物理化学性质&存储条件

参考文献

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