ADU-S100 (ML RR-S2 CDA ammonium salt, MIW815) | STING agonist

Chemical Structure : ADU-S100 ammonium salt

CAS No.: 1638750-96-5

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ADU-S100 ammonium salt (2’3’-c-di-AM(PS)2 (Rp,Rp) (ammonium salt), ML RR-S2 CDA, MIW815)

货号: PC-43284Not For Human Use, Lab Use Only.

ML RR-S2 CDA ammonium salt is a synthetic cyclic dinucleotide derivative that functions as a highly potent agonist of STING, enhances binding affinity to STING and activates all known human STING alleles.

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1 mg	￥2480	In stock
5 mg	￥4280	In stock
10 mg	￥7280	In stock
25 mg		Get quote

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生物&药学活性

ADU-S100 (ML RR-S2 CDA ammonium salt, MIW815) is a synthetic cyclic dinucleotide derivative that functions as a highly potent agonist of STING, enhances binding affinity to STING and activates all known human STING alleles.
ML RR-S2 CDA ammonium salt shows enhanced type I IFN production over CDA in THP-1 human monocytes, induces the highest expression of IFN-β and the pro-inflammatory cytokines TNF-α, IL-6, and MCP-1 on a molar equivalent basis, as compared to endogenous ML cGAMP and the TLR3 agonist poly I:C.
ML RR-S2 CDA ammonium salt also induces aggregation of STING and induces phosphorylation of TBK1 and IRF3 in mouse BMM, induces significantly higher levels of IFN-α when compared to ML cGAMP.
ML RR-S2 CDA ammonium salt demonstrates profound anti-tumor efficacy in established B16 melanoma.

物理化学性质&存储条件

分子量	724.604124
分子式	C20H30N12O10P2S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: 15 mg/mL; H2O: 12.5 mg/mL
Chemical Name/SMILES	Adenosine, [P(R)]-5'-O-[(R)-hydroxymercaptophosphinyl]-P-thioadenylyl-(2'→5')-, cyclic nucleotide, ammonium salt (1:2)

参考文献

1. Corrales L, et al. Cell Rep. 2015 May 19;11(7):1018-30.

ADU-S100 ammonium salt (2’3’-c-di-AM(PS)2 (Rp,Rp) (ammonium salt), ML RR-S2 CDA, MIW815)

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物理化学性质&存储条件

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ADU-S100 ammonium salt (2’3’-c-di-AM(PS)2 (Rp,Rp) (ammonium salt), ML RR-S2 CDA, MIW815)

生物&药学活性

物理化学性质&存储条件

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