ADU-S100 | STING agonist | Probechem Biochemicals

Chemical Structure : ADU-S100

CAS No.: 1638241-89-0

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ADU-S100 (2’3’-c-di-AM(PS)2 (Rp,Rp), MIW815, ML RR-S2 CDA)

货号: PC-43283Not For Human Use, Lab Use Only.

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1 mg	￥2880	In stock
2 mg	￥4580	In stock
5 mg	￥7580	In stock
10 mg		Get quote

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生物&药学活性

ADU-S100 (MIW815, ML RR-S2 CDA) is a synthetic cyclic dinucleotide derivative that functions as a highly potent agonist of STING, enhances binding affinity to STING and activates all known human STING alleles.
ADU-S100 shows enhanced type I IFN production over CDA in THP-1 human monocytes, induces the highest expression of IFN-β and the pro-inflammatory cytokines TNF-α, IL-6, and MCP-1 on a molar equivalent basis, as compared to endogenous ML cGAMP and the TLR3 agonist poly I:C.
ADU-S100 also induces aggregation of STING and induces phosphorylation of TBK1 and IRF3 in mouse BMM, induces significantly higher levels of IFN-α when compared to ML cGAMP.
ADU-S100 demonstrates profound anti-tumor efficacy in established B16 melanoma.

物理化学性质&存储条件

分子量	690.5431
分子式	C20H24N10O10P2S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Adenosine, [P(R)]-5'-O-[(R)-hydroxymercaptophosphinyl]-P-thioadenylyl-(2'→5')-, cyclic nucleotide

参考文献

1. Corrales L, et al. Cell Rep. 2015 May 19;11(7):1018-30.

ADU-S100 (2’3’-c-di-AM(PS)2 (Rp,Rp), MIW815, ML RR-S2 CDA)

生物&药学活性

物理化学性质&存储条件

参考文献

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ADU-S100 (2’3’-c-di-AM(PS)2 (Rp,Rp), MIW815, ML RR-S2 CDA)

生物&药学活性

物理化学性质&存储条件

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