ADS1017 trihydrochloride

Chemical Structure : ADS1017 trihydrochloride

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货号: PC-23593Not For Human Use, Lab Use Only.

ADS1017 trihydrochloride is a potent, selective histamine H3 receptor antagonist with pKi of 7.9/6.8 for rH3R/hH3R in radioligand binding assays respectively, 20-fold selective over H4R.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

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生物&药学活性

ADS1017 trihydrochloride is a potent, selective histamine H3 receptor antagonist with pKi of 7.9/6.8 for rH3R/hH3R in radioligand binding assays respectively, 20-fold selective over H4R.
ADS1017 demonstrates marked H3 receptor antagonist activity in the guinea pig jejunum functional assay (gpH3R pA2 = 8.21) and weak but competitive antagonism toward H1R with pA2 = 6.70.
ADS1017 shows a broad spectrum of analgesic activity in both nociceptive and neuropathic pain models.

物理化学性质&存储条件

分子量	589.09
分子式	C29H48Cl3N5O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-benzyl-1-(4-(4-(7-phenoxyheptyl)piperazin-1-yl)butyl)guanidine trihydrochloride

参考文献

1. Karcz T, et al. ACS Chem Neurosci. 2024 Dec 9. doi: 10.1021/acschemneuro.4c00480.