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首页-小分子抑制剂&激动剂-Immunology/Inflammation-NOD-like Receptor (NLR)-ADS032
ADS032

Chemical Structure : ADS032

CAS No.: 2757333-37-0

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ADS032 (ADS-032)

货号: PC-20956Not For Human Use, Lab Use Only.

ADS032 (ADS-032) is the first, reversible and stable dual NLRP1 and NLRP3 inflammasome inhibitor, inhibits nigericin‐induced NLRP3‐induced IL‐1β secretion from LPS‐primed iBMDMs with IC50 of 30 uM.

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5 mg ￥980 In stock
10 mg ￥1480 In stock
25 mg ￥2580 In stock
50 mg ￥4280 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

ADS032 (ADS-032) is the first, reversible and stable dual NLRP1 and NLRP3 inflammasome inhibitor, inhibits nigericin‐induced NLRP3‐induced IL‐1β secretion from LPS‐primed iBMDMs with IC50 of 30 uM.
ADS032 inhibits ionophore‐ (nigericin) and crystalline‐ (silica) induced IL‐1β and LDH secretion from LPS‐primed iBMDMs, respectively, with no effect on LPS‐induced TNF‐α production.
ADS032 dose dependently inhibits IL‐1β secretion induced by the NLRP1 agonist L18‐MDP, but MCC950 has no effect.
ADS032 reduces L18‐MDP‐induced IL‐1β secretion in both WT and NLRP3‐deficient macrophages in a dose‐dependent manner.
ADS032 directly interacts proximal to the Walker B motif within the NACHT domain of both NLRP1 and NLRP3, thus inhibiting inflammasome activation and formation of each inflammasome complex.
ADS032 (20-350 uM) dose dependently reduces NLPR3‐induced ASC oligomerisation.
ADS032 effectively inhibits NLRP1 and NLRP3 inflammasome activity in human macrophages and bronchial epithelial cells.
ADS032 (200 mg /kg, methylcellulose, i.p.) inhibits NLRP3 in vivo and reduces acute silicosis‐associated pulmonary inflammation in vivo.

物理化学性质&存储条件

分子量 403.54
分子式 C22H29NO4S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4-(4'-(N,N-dipropylsulfamoyl)-[1,1'-biphenyl]-4-yl)butanoic acid

参考文献

1. Docherty CA, et al. Clin Transl Immunology. 2023 Jun 22;12(6):e1455.

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