AD2900 | S1P inhibitor | Probechem Biochemicals

Chemical Structure : AD2900

CAS No.: 18360-29-7

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AD2900 (AD 2900, AD-2900)

货号: PC-60340Not For Human Use, Lab Use Only.

AD 2900 (AD2900, AD-2900) is a novel potent, broad S1P receptor antagonist with IC50 of 3.8, 3.2, 6.2, 5.9 and 0.405 uM for S1P1, 2, 3, 4 and 5 respectively.

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10 mg	￥3980	In stock
25 mg	￥5980	In stock
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生物&药学活性

AD 2900 (AD2900, AD-2900) is a novel potent, broad S1P receptor antagonist with IC50 of 3.8, 3.2, 6.2, 5.9 and 0.405 uM for S1P1, 2, 3, 4 and 5 respectively.
AD 2900 shows no significant agonism effects (EC50>50 uM); suppresses PBMC proliferation, regulates the expression of S1P1 and CCR7 on PBMCs.
AD 2900 accumulates T cells in the blood and spleen and in turn reduces T-cell number in the lymph nodes.
AD 2900 shows significant effects on the localization of T-cell subpopulations in mice.

物理化学性质&存储条件

分子量	345.568
分子式	C20H43NO3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(hexadecylamino)-2-(hydroxymethyl)propane-1,3-diol

参考文献

1. Song J, et al. Oncotarget. 2017 Jun 27;8(32):53563-53580.

2. Dagan A, et al. Biochim Biophys Acta. 2003 Sep 22;1633(3):161-9.

AD2900 (AD 2900, AD-2900)

生物&药学活性

物理化学性质&存储条件

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AD2900 (AD 2900, AD-2900)

生物&药学活性

物理化学性质&存储条件

参考文献

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