欢迎访问ProbeChem中文网站，英文网站请访问www.probechem.com
    英文 |     中文

产品咨询: sales@probechem.com
订购: order@probechem.com

首页-小分子抑制剂&激动剂-Tyrosine Kinase-Trk Receptor-ACD855
ACD855

Chemical Structure : ACD855

CAS No.: 69004-04-2

加入收藏

ACD855 (Ponazuril, Toltrazuril-sulfone)

货号: PC-23115Not For Human Use, Lab Use Only.

ACD855 (Ponazuril) is a potent, pan-Trk positive allosteric modulator (PAM) with EC50 of 1.9, 3.2 and 0.8 uM for TrkA, TrkB and TrkC respectively.

规格 价格 库存 数量
25 mg ￥980 In stock
50 mg ￥1480 In stock
100 mg ￥2380 In stock
250 mg Get quote
获取报价单
* 请选择数量再加入购物车
 or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

ACD855 (Ponazuril) is a potent, pan-Trk positive allosteric modulator (PAM) with EC50 of 1.9, 3.2 and 0.8 uM for TrkA, TrkB and TrkC respectively.
ACD855 effectively potentiates the response of NGF and BDNF in TrkA- and TrkB-overexpressing cell lines .
ACD855 facilitates LTP induction in hippocampal rat slices. ACD855 (3 or 10 mg/kg, s.c.) reverses memory-impairment in the passive avoidance task in mice.

物理化学性质&存储条件

分子量 457.38
分子式 C18H14F3N3O6S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

1-methyl-3-(3-methyl-4-(4-((trifluoromethyl)sulfonyl)phenoxy)phenyl)-1,3,5-triazinane-2,4,6-trione

参考文献

1. Dahlström M, et al. Cells. 2021 Jul 23;10(8):1871.

2. Madjid N, et al. Psychopharmacology (Berl). 2023 Aug;240(8):1789-1804.

备案号：沪ICP备16042516号-1 Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

联系我们 sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

询单

  • *产品名称:
  • *姓名:
  • *邮箱:
  • *公司名称:
  • *询单数量:
  • *国籍:
  • 询单信息: