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首页-小分子抑制剂&激动剂-GPCR-Histamine Receptor-ABT-288
ABT-288

Chemical Structure : ABT-288

CAS No.: 948845-91-8

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ABT-288 (ABT288)

货号: PC-63032Not For Human Use, Lab Use Only.

ABT-288 is a potent, selective and competitive antagonist of H3 receptor with Ki of 1.9/8.2 nM for human/rat H3 respectively.

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5 mg ￥2980 In stock
10 mg ￥4780 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

ABT-288 is a potent, selective and competitive antagonist of H3 receptor with Ki of 1.9/8.2 nM for human/rat H3 respectively.
ABT-288 enhances the release of acetylcholine and dopamine in rat prefrontal cortex.
ABT-288 possesses excellent pharmacokinetics and oral bioavailability.

物理化学性质&存储条件

分子量 372.472
分子式 C23H24N4O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-[4'-((3aR,6aR)-5-methyl-hexahydro-pyrrolo[3,4-b]pyrrol-1-yl)-biphenyl-4-yl]-2H-pyridazin-3-one

参考文献

1. Esbenshade TA, et al. J Pharmacol Exp Ther. 2012 Oct;343(1):233-45.

2. Hudzik TJ, et al. Psychopharmacology (Berl). 2013 Jul;228(2):187-97.

3. Othman AA, et al. Br J Clin Pharmacol. 2014 Jun;77(6):965-74.

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