AB1 |CAS:1463912-49-3 Probechem Biochemicals

Chemical Structure : AB1

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AB1 (AB-1;AB 1)

货号: PC-60746Not For Human Use, Lab Use Only.

AB1 is a potent, specific S1P2 receptor (Edg-5) antagonist with IC50 of 3 nM, with no agonistic or antagonistic activities on other S1PRs.

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1 g		Get quote

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生物&药学活性

AB1 is a potent, specific S1P2 receptor (Edg-5) antagonist with IC50 of 3 nM, with no agonistic or antagonistic activities on other S1PRs.
AB1 is more effective than JTE-013 in blocking S1P2-mediated inhibition of cell migration in nuroblastoma, inhibits (C-C motif) ligand 2 expression and significantly inhibits subsequent tumor-associated macrophage infiltration in neuroblastoma xenografts.
AB1 induces apoptosis and shows antitumor activity in neuroblastoma models.

物理化学性质&存储条件

分子量	434.325
分子式	C19H21Cl2N7O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(1H-4-isopropyl-1-allyl-3-methylpyrazolo[3,4-b]pyridine-6-yl)-amino-N'-(2,6-dichloropyridine-4-yl) urea

参考文献

1. Li MH, et al. J Pharmacol Exp Ther. 2015 Sep;354(3):261-8.

AB1 (AB-1;AB 1)

生物&药学活性

物理化学性质&存储条件

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AB1 (AB-1;AB 1)

生物&药学活性

物理化学性质&存储条件

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