(R)-DRF053 dihydrochloride |CAS:1241675-76-2 Probechem Biochemicals

Chemical Structure : (R)-DRF053 dihydrochloride

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(R)-DRF053 dihydrochloride (DRF 053;DRF053)

货号: PC-60582Not For Human Use, Lab Use Only.

(R)-DRF053 dihydrochloride (DRF053) is a potent, cell-permeable, dual CK1/CDK inhibitor with IC50 of 14 nM, 220 nM and 80 nM for CK1, CDK5/p25 and CDK1/cyclin B, respectively.

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生物&药学活性

(R)-DRF053 dihydrochloride (DRF053) is a potent, cell-permeable, dual CK1/CDK inhibitor with IC50 of 14 nM, 220 nM and 80 nM for CK1, CDK5/p25 and CDK1/cyclin B, respectively.
(R)-DRF053 exhibits antiproliferative activity against human neuroblastoma SH-SY5Y cells with EC50 of 17.2 uM, prevents the CK1-dependent production of amyloid-beta in a cell model.
(R)-DRF053 specifically increases the number of duct-derived β-cells without affecting their proliferation.

物理化学性质&存储条件

分子量	490.433
分子式	C23H29Cl2N7O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-2-((9-isopropyl-6-((3-(pyridin-2-yl)phenyl)amino)-9H-purin-2-yl)amino)butan-1-ol dihydrochloride

参考文献

1. Oumata N, et al. J Med Chem. 2008 Sep 11;51(17):5229-42.

2. Zelenak C, et al. Cell Physiol Biochem. 2012;29(1-2):171-80.

3. Liu KC, et al. Diabetes. 2018 Jan;67(1):58-70.

(R)-DRF053 dihydrochloride (DRF 053;DRF053)

生物&药学活性

物理化学性质&存储条件

参考文献

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(R)-DRF053 dihydrochloride (DRF 053;DRF053)

生物&药学活性

物理化学性质&存储条件

参考文献

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