γ-secretase modulator 14a |CAS:1485066-18-9 Probechem Biochemicals

Chemical Structure : γ-secretase modulator 14a

加入收藏

γ-secretase modulator 14a

货号: PC-60155Not For Human Use, Lab Use Only.

A potent, selective, orally active γ-secretase modulator with Aβ42 IC50 of 39 nM.

规格	价格	库存	数量
25 mg		Get quote
100 mg		Get quote
500 mg		Get quote
1 g		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

A potent, selective, orally active γ-secretase modulator with Aβ42 IC50 of 39 nM; shows good to excellent selectivity for the reduction of Aβ42 in the cellular assays; significantly reduces Aβ42 in the CNS compartment in vivo in nontransgenic rat models.

物理化学性质&存储条件

分子量	418.472
分子式	C24H23FN4O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(4-fluorophenyl)-3-(3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl)-4,5,6,7-tetrahydrobenzo[d]isoxazol-7-amine

参考文献

1. Zhao Z, et al. ACS Med Chem Lett. 2017 Sep 19;8(10):1002-1006.