β-catenin inhibitor C2

Chemical Structure : β-catenin inhibitor C2

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货号: PC-72072Not For Human Use, Lab Use Only.

β-catenin inhibitor C2 is a novel potent selective β-catenin inhibitor with Kd of 54.96 nM, directly to ARM domain of β-catenin.

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10 mg		Get quote
25 mg		Get quote
100 mg		Get quote

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生物&药学活性

β-catenin inhibitor C2 is a novel potent selective β-catenin inhibitor with Kd of 54.96 nM, directly to ARM domain of β-catenin.
β-catenin inhibitor C2 reduced viability of DLD1 and SW480 cells in dose-dependent manner with IC50 ranging between 0.8-1.3 uM, viability of HCT116 and SW48 with IC50 3.45-5.35 uM.
β-catenin inhibitor C2 selectively inhibits β-catenin, lowers its cellular load and significantly reduces viability of β-catenin-driven cancer cells.

物理化学性质&存储条件

分子量	484.25
分子式	C19H20Br2N2OS
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(E)-1-(3,5-dibromo-2-hydroxystyryl)-3-(3a,4,5,6,7,7a-hexahydro-1H-4,7-methanoinden-5-yl)thiourea

参考文献

1. Anton Cheltsov, et al. Sci Rep. 2020 May 15;10(1):8096.