β-catenin-IN-37 |CAS:1783856-40-5 Probechem Biochemicals

Chemical Structure : β-catenin-IN-37

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β-catenin-IN-37

货号: PC-61802Not For Human Use, Lab Use Only.

β-catenin-IN-37 is a novel potent, and selective small-molecule inhibitor for the β-catenin/Tcf4 protein-protein interaction with Ki of 17 uM.

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生物&药学活性

β-catenin-IN-37 is a novel potent, and selective small-molecule inhibitor for the β-catenin/Tcf4 protein-protein interaction with Ki of 17 uM.
β-catenin-IN-37 suppresses canonical Wnt signaling, downregulates the expression of Wnt target genes.
β-catenin-IN-37 inhibits the growth of Wnt-activated cancer cells with the IC50 values of 26 uM and 31 uM for SW480 and HCT116 cells, respectively.

物理化学性质&存储条件

分子量	307.277
分子式	C13H9N9O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-(2-(2H-Tetrazol-5-yl)ethyl)-5H-[1,2,5]oxadiazolo[3',4':5,6]-pyrazino[2,3-b]indole

参考文献

1. Catrow JL, et al. J Med Chem. 2015 Jun 11;58(11):4678-92.

β-catenin-IN-37

生物&药学活性

物理化学性质&存储条件

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β-catenin-IN-37

生物&药学活性

物理化学性质&存储条件

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