trans Ned 19

Chemical Structure : trans Ned 19

CAS No.: 1354235-96-3

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货号: PC-62184Not For Human Use, Lab Use Only.

trans Ned 19 is a cell-permeant chemical probe for the Ca(2+)-releasing second messenger NAADP, blocks NAADP signaling (IC50=6 nM, inhibition of Ca2+ release).

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10 mg	￥2980	In stock
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trans Ned 19 is a cell-permeant chemical probe for the Ca(2+)-releasing second messenger NAADP, blocks NAADP signaling (IC50=6 nM, inhibition of Ca2+ release).
trans Ned 19 blocks NAADP signaling and fluorescently labeled NAADP receptors in intact cells.
trans Ned-19 antagonizes NAADP-activation of TPC2 in a non-competitive manner at 1 uM.

物理化学性质&存储条件

分子量	514.601
分子式	C30H31FN4O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(1R,3S)-1-[3-[[4-(2-fluorophenyl)-1-piperazinyl]methyl]-4-methoxyphenyl]-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic acid

参考文献

1. Naylor E, et al. Nat Chem Biol. 2009 Apr;5(4):220-6.

2. Ali RA, et al. J Biol Chem. 2016 Feb 26;291(9):4503-22.

trans Ned 19

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trans Ned 19

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