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首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-PERK-trans-ISRIB
trans-ISRIB

Chemical Structure : trans-ISRIB

CAS No.: 1597403-47-8

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trans-ISRIB (ISRIB trans-isomer)

货号: PC-43062Not For Human Use, Lab Use Only.

ISRIB trans-isomer is a potent inhibitor of PERK signaling, potently reverses the effects of eIF2α phosphorylation with IC50 of 5 nM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

trans-ISRIB is a potent inhibitor of PERK signaling, potently reverses the effects of eIF2α phosphorylation with IC50 of 5 nM.
ISRIB reduces the viability of cells subjected to PERK-activation by chronic endoplasmic reticulum stress, display significant enhancement in spatial and fear-associated learning.
ISRIB is a potent inhibitor of the integrated stress response (ISR)integrated stress response (ISR), 100-fold more potent than cis-ISRIB (IC50=600 nM).

物理化学性质&存储条件

分子量 451.343
分子式 C22H24Cl2N2O4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

DMSO: ≥ 38 mg/mL
Chemical Name/SMILES

Acetamide, N,N'-trans-1,4-cyclohexanediylbis[2-(4-chlorophenoxy)-

参考文献

1. Sidrauski C, et al. Elife. 2013 May 28;2:e00498.

2. Sidrauski C, et al. Elife. 2015 Feb 26;4.

3. Halliday M, et al. Cell Death Dis. 2015 Mar 5;6:e1672.

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