tatM2NX | TRPM2 antagonist | Probechem Biochemicals

Chemical Structure : tatM2NX

CAS No.: 2126166-03-6

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tatM2NX (TAT-M2NX)

货号: PC-72122Not For Human Use, Lab Use Only.

tatM2NX is a novel potent, selective, cell permeable, peptide TRPM2 channel antagonist with IC50 of 396 nM, IC90 of 2 uM (TRPM2 channel currents), prevents ligand binding and TRPM2 activation.

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生物&药学活性

tatM2NX is a novel potent, selective, cell permeable, peptide TRPM2 channel antagonist with IC50 of 396 nM, IC90 of 2 uM (TRPM2 channel currents), prevents ligand binding and TRPM2 activation.
tatM2NX interacts with the ADPR binding site on the NUT9-H domain of TRPM2 channel. tatM2NX inhibits TRPM2-mediated dephosphorylation of GSK3β (activation), tatM2NX demonstrated selective neuroprotective effects in a mouse model of focal ischemia (stroke).

物理化学性质&存储条件

分子量	4354.11
分子式	C190H323N71O45S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Gly-Ser-Arg-Glu-Pro-Gly-Glu-Met-Leu-Pro-Arg-Lys-Leu-Lys-Arg-Val-Leu-Arg-Gln-Glu-Phe-Trp-Val

参考文献

1. Cruz-Torres I, et al. Mol Pharmacol. 2020 Feb;97(2):102-111.

2. Dietz RM, et al. Transl Stroke Res. 2020 Apr;11(2):254-266.

3. Dietz RM, et al. Neural Plast. 2021 Oct 6;2021:8774663.

tatM2NX (TAT-M2NX)

生物&药学活性

物理化学性质&存储条件

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tatM2NX (TAT-M2NX)

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物理化学性质&存储条件

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