slCeMM1

Chemical Structure : slCeMM1

加入收藏

货号: PC-20896Not For Human Use, Lab Use Only.

slCeMM1 is a potent, highly selective inhibitor of lactate transporter SLC16A3 (MCT4), inhibits intracellular lactate accumulation in SLC16A3 dependent cells (IC50=91 nM).

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
200 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

slCeMM1 is a potent, highly selective inhibitor of lactate transporter SLC16A3 (MCT4), inhibits intracellular lactate accumulation in SLC16A3 dependent cells (IC50=91 nM).
slCeMM1 displays no effec on intracellular lactate accumulationt in cells dependent on SLC16A1.
slCeMM1 inhibits growth of HAP1 cells dependent on SLC16A3 (IC50 = 0.88 μM), but not on SLC16A1, SLC16A7 or SLC16A8, and this effect was rescued by re-introduction of SLC16A1WT but not transport-deficient mutant SLC16A1R313Q.
slCeMM1 is a valuable additional tool that helps to chemically validate SLC16A3 as a target based on experiments with gene knock-out/knock-down strategies.

物理化学性质&存储条件

分子量	414.39
分子式	C20H17F3N6O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(5,7-dimethyl-2-(trifluoromethyl)-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl)-N-(quinolin-3-yl)propanamide

参考文献

1. Dvorak V, et al. Cell Chem Biol. 2023 Jul 15:S2451-9456(23)00204-0.

slCeMM1

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

slCeMM1

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.