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首页-小分子抑制剂&激动剂-Nuclear Receptor/Transcription Factor-Keap1-Nrf2-sAKZ692
sAKZ692

Chemical Structure : sAKZ692

CAS No.: 950430-20-3

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sAKZ692 (sAKZ-692, sAKZ 692)

货号: PC-20849Not For Human Use, Lab Use Only.

sAKZ692 (sAKZ-692) is a small molecule activator of NRF2 transcriptional activity (EC50=2.2 uM) in cells by inhibiting the glycolytic enzyme pyruvate kinase.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    sAKZ692 (sAKZ-692) is a small molecule activator of NRF2 transcriptional activity (EC50=2.2 uM) in cells by inhibiting the glycolytic enzyme pyruvate kinase.
    sAKZ692 treatment promotes the buildup of glyceraldehyde 3-phosphate, a metabolite which leads to S-lactate modification of cysteine sensor residues of KEAP1, resulting in NRF2-dependent transcription.

    物理化学性质&存储条件

    分子量 367.36
    分子式 C19H15F2N5O
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N-(2-(5-fluoro-1H-indol-3-yl)ethyl)-1-(4-fluorophenyl)-1H-1,2,3-triazole-4-carboxamide

    参考文献

    1. Yeonjin Ko, et al. Proc Natl Acad Sci U S A. 2023 May 16;120(20):e2300763120.

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