rac Pterosin B | SIK3 inhibitor | Probechem Biochemicals

Chemical Structure : rac Pterosin B

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rac Pterosin B (Pterosine B)

货号: PC-63124Not For Human Use, Lab Use Only.

rac Pterosin B is a potent and specific SIK3 signaling inhibitor that suppresses SIK3 downstream cascades by up-regulating the phosphorylation levels in the SIK3 C-terminal regulatory domain.

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生物&药学活性

rac Pterosin B is a potent and specific SIK3 signaling inhibitor that suppresses SIK3 downstream cascades by up-regulating the phosphorylation levels in the SIK3 C-terminal regulatory domain.
rac Pterosin B shows no effect on up-regulation of MEF2 and down-regulation of CRTC2 activities by SIK1 or SIK2.
rac Pterosin B promotes glucose production by up-regulating gluconeogenic gene expression in mouse hepatoma AML-12 cells, decreases the glycogen content and stimulates an association between PHKG2 and SIK3.

物理化学性质&存储条件

分子量	218.296
分子式	C14H18O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2,3-Dihydro-6-(2-hydroxyethyl)-2,5,7-trimethyl-1H-inden-1-one

参考文献

1. Itoh Y, et al. J Biol Chem. 2015 Jul 17;290(29):17879-93.

2. Yahara Y, et al. Nat Commun. 2016 Mar 24;7:10959.

rac Pterosin B (Pterosine B)

生物&药学活性

物理化学性质&存储条件

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rac Pterosin B (Pterosine B)

生物&药学活性

物理化学性质&存储条件

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