rTRD01

Chemical Structure : rTRD01

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货号: PC-73020Not For Human Use, Lab Use Only.

rTRD01 is a specific small molecule that binds to TDP-43 RRM1 and RRM2 domains (Kd=89 uM), disrupts TDP-43 interaction with the hexanucleotide RNA repeat of the disease-linked c9orf 72 gene.

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生物&药学活性

rTRD01 is a specific small molecule that binds to TDP-43 RRM1 and RRM2 domains (Kd=89 uM), disrupts TDP-43 interaction with the hexanucleotide RNA repeat of the disease-linked c9orf 72 gene.
rTRD01 inhibited (GGGGCC)4 interaction for TDP-43 102–269 with IC50 of 150 uM.
rTRD01 improved larval turning in a Drosophila model of amyotrophic lateral sclerosis (ALS).

物理化学性质&存储条件

分子量	344.39
分子式	C18H21FN4O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	6-[3-(4-Fluorobenzyl)-3-(hydroxymethyl)piperidin-1-yl]pyrazine-2-carboxamide

参考文献

1. François-Moutal L, et al. ACS Chem Biol. 2019 Sep 20;14(9):2006-2013.

rTRD01

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rTRD01

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