proTAME | APC/C inhibitor | Probechem Biochemicals

Chemical Structure : proTAME

CAS No.: 1362911-19-0

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proTAME (pro-Tosyl-L-Arginine Methyl Ester)

货号: PC-63040Not For Human Use, Lab Use Only.

proTAME is a cell permeable prodrug of TAME, which is an anaphase-promoting complex/cyclosome (APC/C) inhibitor that binds to the APC preferentially suppresses APC/C(Cdc20).

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生物&药学活性

proTAME is a cell permeable prodrug of TAME, which is an anaphase-promoting complex/cyclosome (APC/C) inhibitor that binds to the APC preferentially suppresses APC/C(Cdc20).
proTAME arrests cells in metaphase without perturbing the spindle, but is dependent on the spindle assembly checkpoint (SAC).
proTAME efficiently targets osteosarcoma in vitro combined with chemotherapeutic agents.

物理化学性质&存储条件

分子量	726.8
分子式	C34H38N4O12S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	10,12-Dioxa-6,8-diazatetradec-6-enoic acid, 2-[[(4-methylphenyl)sulfonyl]amino]-9,13-dioxo-14-phenyl-7-[[[[(2-phenylacetyl)oxy]methoxy]carbonyl]amino]-, methyl ester, (2S)-

参考文献

1. Zeng X, et al. Cancer Cell. 2010 Oct 19;18(4):382-95.

2. Giovinazzi S, et al. Cell Cycle. 2013 Aug 15;12(16):2598-607.

3. Hu K, et al. Oncotarget. 2014 May 30;5(10):3088-100.

proTAME (pro-Tosyl-L-Arginine Methyl Ester)

生物&药学活性

物理化学性质&存储条件

参考文献

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proTAME (pro-Tosyl-L-Arginine Methyl Ester)

生物&药学活性

物理化学性质&存储条件

参考文献

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