proMMP9-IN-3c |CAS:2138321-18-1 Probechem Biochemicals

Chemical Structure : proMMP9-IN-3c

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proMMP9-IN-3c

货号: PC-61898Not For Human Use, Lab Use Only.

proMMP9-IN-3c is a potent and specific inhibitor of the hemopexin-like domain of MMP-9 (proMMP-9) with Kd of 320 nM.

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生物&药学活性

proMMP9-IN-3c is a potent and specific inhibitor of the hemopexin-like domain of MMP-9 (proMMP-9) with Kd of 320 nM.
proMMP9-IN-3c disrupts MMP-9 homodimerization, prevents association of proMMP-9 with both α4β1 integrin and CD44 and results in dissociation of EGFR.
proMMP9-IN-3c decreases phosphorylation of Src and its downstream target proteins FAK and paxillin in cancer cells.
proMMP9-IN-3c blocks cancer cell invasion of the basement membrane and reduces angiogenesis at 500 nM.

物理化学性质&存储条件

分子量	361.435
分子式	C18H20FN3O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(4-fluorophenyl)-4-(4-oxo-3,4,5,6,7,8-hexahydroquinazolin-2-ylthio)butanamide

参考文献

1. Alford VM, et al. ACS Chem Biol. 2017 Nov 17;12(11):2788-2803.

proMMP9-IN-3c

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物理化学性质&存储条件

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proMMP9-IN-3c

生物&药学活性

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