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首页-小分子抑制剂&激动剂-Tyrosine Kinase-DYRK-proINDY
proINDY

Chemical Structure : proINDY

CAS No.: 719277-30-2

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proINDY

货号: PC-22437Not For Human Use, Lab Use Only.

proINDY is the acetylated derivative prodrug of INDY, which is a potent, selective and ATP-competitive inhibitor of Dyrk1A, effectively recovers Xenopus embryos from head malformation induced by Dyrk1A overexpression.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

proINDY is the acetylated derivative prodrug of INDY, which is a potent, selective and ATP-competitive inhibitor of Dyrk1A, effectively recovers Xenopus embryos from head malformation induced by Dyrk1A overexpression.

物理化学性质&存储条件

分子量 277.34
分子式 C14H15NO3S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(Z)-3-ethyl-2-(2-oxopropylidene)-2,3-dihydrobenzo[d]thiazol-5-yl acetate

参考文献

1. Masaki S, et al. Bioorg Med Chem. 2015 Aug 1;23(15):4434-4441.

2. Ogawa Y, et al. Nat Commun. 2010 Oct 5;1:86.

3. MacDonald J, et al. Mol Cancer Res. 2017 Apr;15(4):371-381.

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