Chemical Structure : pan AMPK activator compound 1
CAS No.:
pan AMPK activator compound 1
(AMPK activator compound 1)
货号: PC-22496Not For Human Use, Lab Use Only.
pan-AMPK activator compound 1 is a potent, selective small molecule pan AMPK activator with EC50 of 25.9/259 nM and 72.7/170 nM for human and rat α1β2γ1/α2β1γ1, respectively.
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纯度 & COA & 质检文件 纯度:
>98% (HPLC)
生物&药学活性
pan-AMPK activator compound 1 is a potent, selective small molecule pan AMPK activator with EC50 of 25.9/259 nM and 72.7/170 nM for human and rat α1β2γ1/α2β1γ1, respectively.
pan-AMPK activator compound 1 dose-dependently activates AMPK in whole blood cells and kidney.
pan-AMPK activator compound 1 improves kidney function and protects the tubules.
pan-AMPK activator compound 1 suppresses hypoxia-induced apoptosis in proximal tubule cells by improving the efficiency of oxidative phosphorylation.
pan-AMPK activator compound 1 preserves kidney function during ischemia/reperfusion injury in rats.
物理化学性质&存储条件
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分子量
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486.91
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分子式
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C23H23ClN4O6
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外观性状
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Solid
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CAS No.
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储存条件
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- 固体粉末
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-20°C 12 个月; 4°C 6 个月
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- 配置液
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-80°C 6 个月; -20°C 6 个月
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(3R,3aR,6R,6aR)-6-((6-chloro-5-((R)-1,2,4a,5-tetrahydro-4H-benzo[b][1,4]oxazino[4,3-d][1,4]oxazin-8-yl)-1H-imidazo[4,5-b]pyridin-2-yl)oxy)hexahydrofuro[3,2-b]furan-3-ol
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参考文献
1. Frikke-Schmidt H, et al. J Pharmacol Exp Ther. 2024 Jun 7:JPET-AR-2024-002120.
