pan-PIM inhibitor 27 | Pim inhibitor | Probechem Biochemicals

Chemical Structure : pan-PIM inhibitor 27

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pan-PIM inhibitor 27 (SARxxxx92)

货号: PC-38740Not For Human Use, Lab Use Only.

pan-PIM inhibitor 27 (SARxxxx92) is a potent, selective, orally bioavailable pan-PIM kinase inhibitor with IC50 of 1, 6 nM for Pim1 and Pim2, respectively.

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生物&药学活性

pan-PIM inhibitor 27 (SARxxxx92) is a potent, selective, orally bioavailable pan-PIM kinase inhibitor with IC50 of 1, 6 nM for Pim1 and Pim2, respectively.
pan-PIM inhibitor 27 displays a very favorable selectivity profile against an internal panel of 192 kinases.
pan-PIM inhibitor 27 exhibits potent cellular activity with pS6EC50 of 71 nM, inhibits KG1 cell viability with IC50 of 61 nM.
pan-PIM inhibitor 27 (50-150 mg/kg, p.o. bid) inhibits tumor growth in KG1 mouse xenograph model.

物理化学性质&存储条件

分子量	324.784
分子式	C15H18ClFN4O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-chloro-1-((S)-1-((S)-3-fluoropyrrolidin-3-yl)ethyl)-3-methyl-1H-pyrrolo[2,3-b]pyridine-6-carboxamide

参考文献

1. Claude Barberis, et al. Bioorg Med Chem Lett. 2020 Dec 1;30(23):127625.

pan-PIM inhibitor 27 (SARxxxx92)

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物理化学性质&存储条件

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pan-PIM inhibitor 27 (SARxxxx92)

生物&药学活性

物理化学性质&存储条件

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