pan-PIM inhibitor 17 |CAS:1681021-52-2 Probechem Biochemicals

Chemical Structure : pan-PIM inhibitor 17

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pan-PIM inhibitor 17

货号: PC-35943Not For Human Use, Lab Use Only.

pan-PIM inhibitor 17 is a potent, selective, orally available inhibitor of Pim kinase with IC50 of 0.8, 5.1 and 1.8 nM for Pim1, 2 and 3, respectively.

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25 mg		Get quote
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

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生物&药学活性

pan-PIM inhibitor 17 is a potent, selective, orally available inhibitor of Pim kinase with IC50 of 0.8, 5.1 and 1.8 nM for Pim1, 2 and 3, respectively.
pan-PIM inhibitor 17 disaplays broad selectivity in an internal panel of 192 kinases, only eight kinases were inhibited above 50% at 1 uM.
demonstrates cellular biomarker pS6 inhibition with EC50 of 27 nM, shows tumor growth inhibition in a KG1 tumor-bearing mouse model.

物理化学性质&存储条件

分子量	374.869
分子式	C19H23ClN4O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-4-chloro-2-(4-methoxybut-1-yn-1-yl)-3-methyl-1-(piperidin-3-yl)-1H-pyrrolo[2,3-b]pyridine-6-carboxamide

参考文献

1. Barberis C, et al. Bioorg Med Chem Lett. 2018 Dec 10. pii: S0960-894X(18)30949-1.

2. Barberis C, et al. Bioorg Med Chem Lett. 2017 Oct 15;27(20):4735-4740.

3. Guo Z, et al. Blood. 2014 Sep 11;124(11):1777-89.