pan-IFN inhibitor 5k | JAK-STAT inhibitor | Probechem Biochemicals

Chemical Structure : pan-IFN inhibitor 5k

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pan-IFN inhibitor 5k (JAK-STAT inhibitor)

货号: PC-38756Not For Human Use, Lab Use Only.

pan-IFN inhibitor 5k is a potent and selective inhibitor of interferon-induced JAK-STAT signalling, blocks IFNγ activation of JAK-STAT signalling, also inhibits type I and III IFN-induced STAT phosphorylation in vitro.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

pan-IFN inhibitor 5k is a potent and selective inhibitor of interferon-induced JAK-STAT signalling, blocks IFNγ activation of JAK-STAT signalling, also inhibits type I and III IFN-induced STAT phosphorylation in vitro.
pan-IFN inhibitor 5k selectively inhibits IFN-induced tyrosine phosphorylation of STAT1 and STAT2, with no significant effect on STAT1 activation by EGF.
pan-IFN inhibitor 5k reduces bleeding in model of haemorrhagic colitis in vivo.

物理化学性质&存储条件

分子量	434.417
分子式	C23H12F2N2O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-((5-ethynylfuran-2-yl)methylene)-1,3-bis(3-fluorophenyl)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione

参考文献

1. Thoidingjam LK, et al. Angew Chem Int Ed Engl. 2022 May 25.