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首页-小分子抑制剂&激动剂-Proteasome/Ubiquitin-Proteasome-o-Phenanthroline
o-Phenanthroline

Chemical Structure : o-Phenanthroline

CAS No.: 66-71-7

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o-Phenanthroline (1,10-phenanthroline, Ortho-phenanthroline, OPA)

货号: PC-61352Not For Human Use, Lab Use Only.

o-Phenanthroline is a selective inhibitor of 26S proteasome subunit Rpn11 with IC50 of 10±2 uM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

o-Phenanthroline is a selective inhibitor of 26S proteasome subunit Rpn11 with IC50 of 10±2 uM.
o-Phenanthroline shows no activity for other DUBs (USP1/USP2/USP4/USP5/USP7/USP8/USP20/UCH37, IC50>50 uM).
o-Phenanthroline blocks cellular proteasome function, induces apoptosis in MM cells and overcomes resistance to proteasome inhibitor bortezomib, activates caspase cascade and endoplasmic stress response signaling.
o-Phenanthroline reduces progression of tumor growth and prolongs survival in mice MM xenograft model.

物理化学性质&存储条件

分子量 180.21
分子式 C12H8N2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4,5-Diazaphenanthrene

参考文献

1. Song Y, et al. Oncogene. 2017 Jun 5. doi: 10.1038/onc.2017.172.

2. Verma R, et al. Science. 2002 Oct 18;298(5593):611-5.

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